I have been having the same issue and actually looked on the forum to see if anyone else was having this problem. I run Windows7 and SAS 4.44.1000. Sometimes my PC starts up fine but other times it locks up when trying to start SAS. I think if there was a way to delay opening SAS by a couple of minutes on start up it would solve the problem. I also run Malwarebytes and Kaspersky Anti Virus 2011.